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The long term goal of the Biomaterials and Interface Tissue Engineering Laboratory (BITEL) is to design nano-biomaterials and functional tissue grafts that have the ability to direct cellular responses, regulate the formation and integration of multiple tissue types, and address challenges associated with aging and mobility. Our research focuses on sustainable biomaterial design and composite tissue regeneration through engineering nanomaterials, harnessing living materials/drugs and stem cells, and developing biofabrication and machine learning techniques. Mechanisms of cell-material interaction and complex tissue regeneration strategies developed at BITEL have broad application in sports medicine, women’s health and oral health, and address grand challenges in Engineering for a Healthy Humanity